β-Muricholic Acid - Names and Identifiers
Name | β-Muricholic Acid
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Synonyms | 6β 7β-triol β-Muricholic Acid 5β-Cholanic Acid-3α Ursodeoxycholic Acid Impurity 30 3a,6b,7b-Trihydroxy-5b-cholanoic acid (3α,5β,6β,7β)-3,6,7-Trihydroxycholan-24-oic acid (3a,5b,6b,7b)-3,6,7-trihydroxy-Cholan-24-oic acid
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CAS | 2393-59-1
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β-Muricholic Acid - Physico-chemical Properties
Molecular Formula | C24H40O5
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Molar Mass | 408.57 |
Density | 1.184±0.06 g/cm3(Predicted) |
Melting Point | 226 °C |
Boling Point | 565.7±40.0 °C(Predicted) |
Solubility | DMSO (Slightly), Ethanol (Slightly,Sonicated), Methanol (Slightly), Water (Sligh |
Appearance | powder |
Color | white to beige |
pKa | 4.76±0.10(Predicted) |
Storage Condition | -20°C |
Use | Use β-murine cholic acid is a bile acid present in urine. β-murine cholic acid has been used to investigate down-regulation of transporters by ubiquitin-dependent protein degradation. |
β-Muricholic Acid - Reference
Reference Show more | 1. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |
β-Muricholic Acid - Introduction
Β-muricholic Acid(β-muricholic Acid) is a secondary bile Acid with the chemical formula C24H40O5. It is one of the primary secondary bile acids in bile and is produced primarily by the liver of mammals. The following is a description of the nature, use, preparation and safety information of β-muricholic Acid:
Nature:
- β-muricholic Acid is a white crystalline solid with weak acidity at room temperature.
-It is deliquescent and soluble in ethanol, chloroform and benzene.
The solution of-β-muricholic Acid exhibits typical bile Acid properties and can be hydrolyzed to bile salts by bile salt hydrolyzing esterase.
Use:
- β-muricholic Acid has certain uses in the medical field, such as as a research tool for liver diseases and biliary tract diseases.
-It can also be used to study bile acid metabolism and the function of bile acid binding proteins.
Preparation Method:
The preparation method of-β-muricholic Acid is mainly obtained by the synthesis route of the classic cholic Acid parent core structure. This typically involves multiple steps starting from cholesterol, such as oxidation, keto-alcohol translocation, and oxidative dehydrogenation, among others.
Safety Information:
- β-muricholic Acid is not significantly toxic or irritant to humans under normal conditions.
-However, as a chemical substance, necessary laboratory safety measures should be taken to avoid direct inhalation, contact with skin and ingestion in the mouth during contact.
-Avoid contact with oxidants and strong acids during handling and storage to prevent dangerous reactions.
-If you come into contact with beta-muricholic Acid, rinse immediately with plenty of water and seek medical help.
Last Update:2024-04-09 20:13:35